The Metabolism of Gentisic Acid and the Ethanolamide of Gentisic Acid
نویسندگان
چکیده
The absorption and excretion of gentisic acid has been studied to help clarify the confusion that exists in the literature. Data are given that support the retarding action of methyl cellulose and Benemid and also the manner in which these compounds are metabolized in the human body. The first metabolic study of the ethanolamide of gentisic acid in human subjects is described. Evidence is presented that the antirheumatic property of certain phenolic compounds may be explained by the phenomena of chelation and the possible existence of a reversible hydroquinone-quinone system in the blood stream.
منابع مشابه
Phenolic compounds in the treatment of rheumatic fever. II. The metabolism of gentisic acid and the ethanolamide of gentisic acid.
The absorption and excretion of gentisic acid has been studied to help clarify the confusion that exists in the literature. Data are given that support the retarding action of methyl cellulose and Benemid and also the manner in which these compounds are metabolized in the human body. The first metabolic study of the ethanolamide of gentisic acid in human subjects is described. Evidence is prese...
متن کاملPhenolic compounds in the treatment of rheumatic fever. I. A study of gentisic acid derivatives.
The chemical compounds known to suppress the manifestations of rheumatic fever are reviewed and the antirheumatic nature of certain phenolic compounds discussed. We report on 75 patients with acute rheumatic fever who have been treated with gentisate compounds and discuss the records of 44 of these patients who have been followed for 3 to 20 months after discontinuing drug therapy. These patien...
متن کاملPhenolic Compounds in the Treatment of Rheumatic Fever
The chemical compounds known to suppress the manifestations of rheumatic fever are reviewed and the antirheumatic nature of certain phenolic compounds discussed. We report on 75 patients with acute rheumatic fever who have been treated with gentisate compounds and discuss the records of 44 of these patients who have been followed for 3 to 20 months after discontinuing drug therapy. These patien...
متن کاملMetabolism of 2-hydroxy-1-naphthoic acid and naphthalene via gentisic acid by distinctly different sets of enzymes in Burkholderia sp. strain BC1.
Burkholderia sp. strain BC1, a soil bacterium, isolated from a naphthalene balls manufacturing waste disposal site, is capable of utilizing 2-hydroxy-1-naphthoic acid (2H1NA) and naphthalene individually as the sole source of carbon and energy. To deduce the pathway for degradation of 2H1NA, metabolites isolated from resting cell culture were identified by a combination of chromatographic and s...
متن کاملSiderocalin/Lcn2/NGAL/24p3 Does Not Drive Apoptosis Through Gentisic Acid Mediated Iron Withdrawal in Hematopoietic Cell Lines
Siderocalin (also lipocalin 2, NGAL or 24p3) binds iron as complexes with specific siderophores, which are low molecular weight, ferric ion-specific chelators. In innate immunity, siderocalin slows the growth of infecting bacteria by sequestering bacterial ferric siderophores. Siderocalin also binds simple catechols, which can serve as siderophores in the damaged urinary tract. Siderocalin has ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2005